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Can Pregnancy Cause Chronic Fatigue Syndrome?

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31 May 2024
Can Pregnancy Cause Chronic Fatigue Syndrome: a rumpled bed in a neutral tones

Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex, long-term illness characterized by extreme fatigue that cannot be explained by any underlying medical condition. The fatigue worsens with physical or mental activity but doesn't improve with rest.

With pregnancy being a significant physiological event, it's not uncommon to wonder: can pregnancy cause chronic fatigue syndrome?

Understanding Chronic Fatigue Syndrome

Chronic Fatigue Syndrome affects up to 2.5 million Americans, according to the Centers for Disease Control and Prevention (CDC) . The condition manifests with various symptoms, including sleep problems, muscle pain, joint pain without swelling, headaches, and cognitive difficulties.

Can Pregnancy Cause Chronic Fatigue Syndrome?

Can Pregnancy Cause Chronic Fatigue Syndrome: close up of a woman's baby bump, she's in an all white outfit laying down

Currently, there is no direct evidence to suggest that pregnancy can cause Chronic Fatigue Syndrome. However, pregnancy induces significant hormonal, immunological, and physiological changes, which could potentially trigger or exacerbate existing conditions, including CFS.

Pregnancy leads to substantial hormonal fluctuations, including increased levels of estrogen and progesterone, which can affect the immune system and possibly influence conditions like CFS.

Further, the immune system undergoes changes during pregnancy to accommodate the growing fetus. This modulation can sometimes lead to an increased susceptibility to infections and other immune-related conditions, potentially impacting fatigue levels.

Chronic Fatigue Syndrome After Pregnancy

Can Pregnancy Cause Chronic Fatigue Syndrome: a baby and mother are napping together on a bed, but all you can see are their legs resting on the sheets

Research suggests that women are more likely to develop CFS during periods of significant hormonal change, such as puberty, pregnancy, and menopause. The Norwegian population-based study on CFS showed a significant incidence of the syndrome in women undergoing puberty and aged 30 to 39, which aligns with the childbearing years

While pregnancy itself may not cause CFS, many women report increased fatigue postpartum. The postpartum period involves recovery from childbirth, sleep deprivation due to newborn care, and emotional adjustments, all of which can contribute to persistent fatigue.

Women can experience severe fatigue lasting several months after childbirth, which can mimic the symptoms of CFS. Alternatively, there’s also a high chance of postpartum depression, which can also include lethargy and fatigue. 

The overlap of these symptoms with postpartum depression and other postpartum disorders can complicate diagnosis. Therefore, it's essential for new mothers experiencing these symptoms to seek medical advice to rule out other potential causes and to receive appropriate treatment.


While there is no conclusive evidence that pregnancy can cause Chronic Fatigue Syndrome, the significant changes and demands of pregnancy and the postpartum period can exacerbate symptoms in women who are susceptible or already dealing with CFS. Understanding the signs and seeking timely medical advice is crucial for managing health effectively during and after pregnancy.

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